PubMed Search


  • Benisty H, Moberly AH, Lohani S, Barson D, Coifman RR, Mishne G, Cardin JA, Higley MJ (2021) Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior.  BioRXiv,
  • Chiu CQ*, Morse TM*, Nani F, Knoflach F, Hernandez M-C, Jadi M, Higley MJ (2020) Tonic GABAergic activity facilitates dendritic calcium signaling and short-term plasticity.  BioRXiv,


  • Cardin JA, Higley MJ (2022) Spatiotemporal dynamics in large-scale cortical networks.  Current Opinion in Neurobiology 77:102627.  [pdf]
  • Lake EMR, Higley MJ (2022) Building bridges: simultaneous multimodal imaging approaches for exploring the oganization of brain networks.  Neurophotonics 9:032202. [pdf]
  • Lohani S*, Moberly AH, Benisty H, Landa B, Jing M, Li Y, Higley MJ*, Cardin JA*.  (2022) Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity.  Nature Neuroscience 25:1706. [pdf]


  • Barson D*, Hamodi AS*, Shen X, Lur G, Constable RT. Cardin JA, Crair MC, Higley MJ (2020) Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits.  Nature Methods 17:107.  [pdf]
  • Tang L, Higley MJ (2020) Layer 5 circuits in V1 differentially control visuomotor behavior.  Neuron 105:346.  [pdf]
    • see Preview:  Xu N (2020) Deciphering pyramidal neuron diversity: delineating perceptual functions of projection-defined neuronal types.  Neuron 105:209.
  • Disney AA and Higley MJ (2020) Diverse spatiotemporal scales of cholinergic signaling in the neocortex.  Journal of Neuroscience 40:720.  [pdf]
  • Puscian A, Benisty H, Higley MJ (2020) NMDAR-dependent emergence of behavioral representation in primary visual cortex.  Cell Reports 32:107970.  [pdf]
  • Lake E, Ge X, Shen X, Herman P, Hyder F, Cardin JA, Higley MJ, Scheinost D, Papademetris X, Crair MC, Constable RT (2020) Simultaneous cortex-wide fluorescence Ca2+ imaging and whole-brain fMRI.  Nature Methods 17:1262.
  • Cardin JA, Crair MC, Higley MJ (2020) Mesoscopic imaging: shining a wide light on large-scale neural dynamics.  Neuron 108:33.  [pdf]


  • Lur G, Fariborzi M, Higley MJ (2019) Ketamine disrupts neuromodulatory control of glutamatergic synaptic transmission.  PLoS One 14:e0213721.  [pdf]
  • Chiu CQ, Barberis A, Higley MJ (2018) Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity.  Nature Reviews Neuroscience 20:272.  [pdf]


  • Chiu CQ, Martenson JS, Yamazaki M, Natsume R, Sakimura K, Tomita S, Tavalin SJ, Higley MJ (2018) Input-specific NMDAR-dependent potentiation of dendritic GABAergic inhibition.  Neuron 97:368.  [pdf]
  • Bessaih T, Higley MJ, Contreras D (2018) Millisecond precision temporal encoding of stimulus features during cortically generated gamma oscillations in the rat somatosensory cortex.  J Physiology 596:515.  [pdf]
  • Chang JT, Higley MJ (2018) Potassium channels contribute to activity-dependent scaling of dendritic inhibition.  Physiological Reports 6:e13747.  [pdf]


  • Batista-Brito R, Vinck M, Ferguson KA, Chang JT, Laubender D, Lur G, Mossner JM, Hernandez VG, Ramakrishnan C, Deisseroth K, Higley MJ, Cardin JA (2017) Developmental dysfunction of VIP interneurons impairs cortical circuits.  Neuron 95:884.  [pdf]


  • Xiao X, Levy AD, Rosenberg BJ, Higley MJ, Koleske AJ (2016) Disruption of coordinated presynaptic and postsynaptic maturation underlies the defects in hippocampal synapse stability and plasticity in Abl2/Arg-deficient mice.  J Neuroscience 36:6778.  [pdf]
  • Kannan M, Gross GG, Arnold DB, Higley MJ (2016) Visual deprivation during the critical period enhances layer 2/3 GABAergic inhibition in mouse V1.  J Neuroscience 36:5914.  [pdf]
  • Lur G, Vinck MA, Tang L, Cardin JA, Higley MJ (2016) Projection-specific feature encoding by layer 5 cortical subnetworks.  Cell Reports 14:2538.  [pdf]


  • Lur G, Higley MJ (2015) Glutamate receptor modulation is restricted to synaptic microdomains.  Cell Reports 12:326.  [pdf]
  • Gamo NJ, Lur G, Higley MJ, Wang M, Paspalas CD, Vijayraghavan S, Yang Y, Ramos BP, Peng K, Kata A, Boven L, Lin F, Roman L, Lee D, Arnsten AF (2015) Stress impairs prefrontal cortical function via D1 dopamine receptor interactions with hyperpolarization-activated cyclic nucleotide-gated channels.  Biol Psychiatry 78:860.  [pdf]


  • Higley MJ (2014) Localized GABAergic inhibition of dendritic calcium signalling.  Nature Reviews Neuroscience 15:567.  [Review]  [pdf]
  • Amatrudo JM, Olson JP, Lur G, Chiu CQ, Higley MJ, Ellis-Davies GC (2014)  Wavelength-selective one- and two-photon uncaging of GABA.  ACS Chem Neurosci 5:64.  [pdf]
  • Higley MJ and Picciotto MR (2014) Neuromodulation by acetylcholine: examples from schizophrenia and depression. Current Opinion in Neurobiology 29:88. [Review]  [pdf]


  • Chiu CQ*, Lur G*, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ (2013)  Compartmentalization of GABAergic inhibition by dendritic spines.  Science 340:759.  [pdf]
    • Commentary: Synaptic transmission: keeping calcium contained. Nature Reviews Neuroscience 14:456.
  • Olson JP, Kwon HB, Takasaki KT, Chiu CQ, Higley MJ, Sabatini BL, Ellis-Davies GC (2013)  Optically selective two-photon uncaging of glutamate at 900 nm.  J Am Chem Soc 135:5954.  [pdf]
  • Einstein EB, Asaka Y, Yeckel MF, Higley MJ, Picciotto MR (2013) Galanin-induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and morphine conditioned place preference require both galanin receptor 1 and galanin receptor 2.  Eur J Neuroscience 37:1541.  [pdf]


  • Picciotto MR, Higley MJ, Mineur YS (2012) Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior. Neuron 76:116-29. [Review]  [pdf]
  • Higley MJ, Sabatini BL (2012) Calcium signaling in dendritic spines. Cold Spring Harb Perspec Biol 4:a005686. [Review]  [pdf]
  • Bessaih T, de Yebenes EG, Kirkland K, Higley MJ, Buono RJ, Ferraro TN, Contreras D (2012) Quantitative trait locus on distal chromosome 1 regulates the occurrence of spontaneous spike-wave discharges in DBA/2 mice.  Epilepsia 53:1429.  [pdf]
  • Higley MJ (2012) Determination of cortical circuit function using current source-density analysis in vivo.  In: Neuronal Network Analysis, Tommaso Fellin and Michael Halassa, eds.  Humana Press.  [pdf]


  • Higley MJ, Gittis AH, Oldenburg IA, Balthasar N, Seal RP, Edwards RH, Lowell BB, Kreitzer AC, Sabatini BL (2011) Cholinergic interneurons mediate fast VGlut3-dependent glutamatergic transmission in the striatum.  PLoS One 6:e19155.  [pdf]


  • Higley MJ, Strittmatter SM (2010) Lynx for braking plasticity.  Science 330:1189. [Comment]  [pdf]
  • Higley MJ, Sabatini BL (2010) Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors.  Nat Neurosci 13:958-66.  [pdf]


  • Higley MJ*, Soler-Llavina GJ*, Sabatini BL (2009) Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration.  Nat Neurosci 12:1121-8.  [pdf]


  • Steiner P, Higley MJ, Xu W, Czervionke BL, Malenka RC, Sabatini BL (2008) Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity.  Neuron 61:152.  [pdf]
  • Higley MJ, Sabatini BL (2008) Calcium signaling in dendrites and spines: practical and functional considerations.  Neuron 59:902.  [Review]  [pdf]
  • Busetto G, Higley MJ, Sabatini BL (2008) Developmental presence and disappearance of postsynaptically silent synapses on dendritic spines of rat layer 2/3 pyramidal neurons.  J Physiol 586:1519-27.  [pdf]


  • Higley MJ, Contreras D (2007) Frequency adaptation modulates spatial integration of sensory responses in the rat whisker system.  J Neurophys 97:3819.  [pdf]
  • Higley MJ, Contreras D (2007) Cellular mechanisms of suppressive interactions between somatosensory responses in vivo.  J Neurophys 97:647.  [pdf]


  • Higley MJ, Contreras D (2006) Balanced excitation and inhibition determine spike timing during frequency adaptation.  J Neurosci 26:448.  [pdf]


  • Higley MJ, Contreras D (2005) Integration of synaptic responses to neighboring whiskers in rat barrel cortex in vivo.  J Neurophys 93:1920.  [pdf]
  • Traub RD, Contreras D, Cunningham MO, Murray H, LeBeau FE, Roopun A, Bibbig A, Wilent WB, Higley MJ, Whittington MA (2005) Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts.  J Neurophys 93:2194.  [pdf]


  • Higley MJ, Contreras D (2003) Nonlinear integration of sensory responses in the rat barrel cortex: an intracellular study in vivo.  J Neurosci 23:10190.  [pdf]


  • Higley MJ, Hermer-Vazquez L, Levitsky DA, Strupp BJ (2001) Recovery of associative function following early amygdala lesions in rats.  Behav Neuroscience 115:154.  [pdf]